Natalizumab-associated PML Update: March 2013

#MSBlog : March natalizumab PML update; 343 confirmed cases with a 23% mortality rate on a denominator of more than 112,000 treated MSers. ...

Survey results: MRI monitoring on natalizumab

"The following are the survey results regarding MRI monitoring of MSers on natalizumab for PML. The good news is that most MSers on nat...

Research: JC virus antibodies

Epub : Warnke et al.   to anti-JCV antibody levels in a Swedish national MS cohort. J Neurol Neurosurg Psychiatry. 2013 Mar 5.  BACKGROUND :...

Natalizumab Safety Update - February 2013

#MSBlog : February 2013 update: 331 natalizumab-related cases of PML; 23% mortality. "As of the 5th February 2013 there have been 331 c...

Occurence of JC Virus in Europe

Epub : Olsson et al. Anti-JC virus antibody prevalence in a multinational multiple sclerosis cohort. Mult Scler. 2013 Mar. Background : JC ...

Research: new assay for JC Virus

# MSBlog : Has your JC virus serological test flipped from being negative to positive? It may be due to the increased sensitivity of the new...

Natalizumab PML & safety update January 2013

#MSBlog : As of the 2 January 2013 there have been 323 confirmed cases of natalizumab-associated PML. "If you are on Natalizumab we wou...

Case report: nipping PML in the bud

#MSBlog : If you are natalizumab, or Tysabri, and are worried about PML this post if for you! Epub : Lindå H, von Heijne A. Presymptomatic d...

Guest post: FUMADERM and PML – can we make conclusions for BG12?

#MSBlog : What does Prof. Gold, the PI on the BG12 programme, have to say about Fumaderm and PML? "In response to the intense interest ...

PML and fumarates

Clarification: I have just found out that the case report below and the third case in the  BfArM's ADR Database (10130944) are the same ...

Research: JC virus T cell responses

#MSBlog : Any immunology geeks interested in the immune response to JCV, the virus that causes PML? Epub : Jelcic et al. T Cell Epitope Mapp...

Research: Imaging PML

Yousry et al.   Magnetic resonance imaging pattern in natalizumab-associated progressive multifocal leucoencephalopathy.   Ann Neurol. 2012;...

Natalizumab PML Risk Stratification Update - December 2012

"As of the 30th November there have been 312 confirmed cases of Natalizumab-related PML! Slide 5, 6 and 19 give you the latest risk str...

Research: JC virus responses & natalizumab

#MSBlog: Steroids reduce the immune response to the JC virus that causes PML. Therefore steroids should only be used to treat not prevent IR...